Douglas N J, White D P, Weil J V, Pickett C K, Zwillich C W
Am Rev Respir Dis. 1982 Nov;126(5):758-62. doi: 10.1164/arrd.1982.126.5.758.
During rapid eye movement (REM) sleep, hypoxia and hypercapnia occur in conjunction with hypoventilation. Although the hypoxic ventilatory response has previously been shown to be reduced in REM sleep, the hypercapnic ventilatory response (HCVR) has not been studied during REM sleep in adult humans. We therefore measured the ventilatory response to hypercapnia in 12 sleeping adults using a modified rebreathing method. The HCVR was significantly reduced in all stages of sleep compared with that during wakefulness (1.60 +/- 0.19 SEM L/min/mmHg CO2), falling to less than half the waking HCVR during non-REM sleep (0.75 +/- 0.08 L/min/mmHg CO2), with a further significant drop during REM sleep when HCVR was less than a third of that during wakefulness (0.45 +/- 0.10 L/min/mmHg CO2). The decreased ventilatory responses to hypercapnia and hypoxia in REM sleep help explain REM-related hypoxemic episodes.
在快速眼动（REM）睡眠期间，低氧血症和高碳酸血症与通气不足同时发生。虽然先前已表明在快速眼动睡眠中低氧通气反应会降低，但尚未对成年人类快速眼动睡眠期间的高碳酸通气反应（HCVR）进行研究。因此，我们使用改良的重复呼吸法测量了12名睡眠中成年人对高碳酸血症的通气反应。与清醒时相比，睡眠各阶段的HCVR均显著降低（清醒时为1.60±0.19 SEM升/分钟/毫米汞柱二氧化碳），在非快速眼动睡眠期间降至清醒时HCVR的一半以下（0.75±0.08升/分钟/毫米汞柱二氧化碳），在快速眼动睡眠期间进一步显著下降，此时HCVR不到清醒时的三分之一（0.45±0.10升/分钟/毫米汞柱二氧化碳）。快速眼动睡眠中对高碳酸血症和低氧血症的通气反应降低有助于解释与快速眼动相关的低氧发作。
