Jennette J C, Ferguson A L, Moore M A, Freeman D G
Arthritis Rheum. 1982 Feb;25(2):144-9. doi: 10.1002/art.1780250205.
Three patients with a seronegative spondylarthropathy were found to have IgA nephropathy. Two patients had ankylosing spondylitis (one with psoriasis), and one had incomplete Reiter's syndrome. All three had a focal proliferative glomerulonephritis with IgA-dominant mesangial immune deposits. One patient had a leukocytoclastic vasculitis. This association of IgA nephropathy with seronegative spondylarthropathies raises the possibility of a common or related pathogenesis. There is evidence to suggest that both diseases are mediated by genetically controlled immune responses to mucosal contact with etiologic antigens.
三名血清阴性脊柱关节病患者被发现患有IgA肾病。两名患者患有强直性脊柱炎（其中一名伴有银屑病），一名患有不完全性赖特综合征。所有三名患者均患有局灶性增生性肾小球肾炎，伴有以IgA为主的系膜免疫沉积物。一名患者患有白细胞破碎性血管炎。IgA肾病与血清阴性脊柱关节病的这种关联增加了存在共同或相关发病机制的可能性。有证据表明，这两种疾病都是由对黏膜接触病原性抗原的基因控制免疫反应介导的。
