Trull A K, Panayi G S
Clin Rheumatol. 1983 Dec;2(4):331-7. doi: 10.1007/BF02041551.
Serum and salivary IgA antibodies to Klebsiella pneumoniae were estimated by enzyme-linked immunosorbent assay (ELISA) in 53 patients with ankylosing spondylitis (AS) and 30 healthy controls. The concentrations of total serum IgA, salivary secretory component (SC) and serum C-reactive protein (CRP) were also measured. In the serum of AS patients there was a positive correlation between Klebsiella IgA antibodies and the CRP. Salivary anti-Klebsiella IgA was elevated in 39% of AS patients although this was not associated with disease activity. Serum and secretory IgA antibodies to E. coli and Pseudomonas aeruginosa were similar in patients and controls irrespective of disease activity. We conclude that part of the increase in salivary and serum IgA in AS may be due to a specific immune response to Klebsiella in the gastrointestinal tract and that serum antibodies reflect more closely those events associated with active inflammatory disease.
通过酶联免疫吸附测定（ELISA）对53例强直性脊柱炎（AS）患者和30名健康对照者检测了血清和唾液中针对肺炎克雷伯菌的IgA抗体。还测定了总血清IgA、唾液分泌成分（SC）和血清C反应蛋白（CRP）的浓度。在AS患者血清中，克雷伯菌IgA抗体与CRP之间存在正相关。39%的AS患者唾液抗克雷伯菌IgA升高，尽管这与疾病活动无关。无论疾病活动情况如何，患者和对照者中针对大肠杆菌和铜绿假单胞菌的血清和分泌型IgA抗体相似。我们得出结论，AS患者唾液和血清IgA增加的部分原因可能是胃肠道对克雷伯菌的特异性免疫反应，并且血清抗体更密切地反映了与活动性炎症疾病相关的情况。
