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[犬正常和刺激搏动时右心室表面兴奋扩散的实验研究]

[Experimental studies on the diffusion of excitation on the right ventricular surface in the dog, during normal and stimulated beats].

作者信息

Arisi G, Macchi E, Baruffi S, Musso E, Spaggiari S, Stilli D, Taccardi B

出版信息

Boll Soc Ital Biol Sper. 1982 Jan;58(1-2):15-21.

PMID:7066094
Abstract

Previous work on the spread of excitation on the dog's ventricular surface enabled us to locate up to 30 breakthrough points (BKTPs) where excitation reaches the ventricular surface. In particular the equipotential contour maps enabled us to detect 3 to 5 BKTPs on the anterior right ventricular surface, near the a-v groove when a large part of ventricular surface was still at rest. With a view to investigating the mechanism underlying the early excitation of these basal regions, we stimulated the heart at several right ventricular BKTPs and in other points located at a distance from the BKTPs. The instantaneous equipotential maps showed that after stimulation most right ventricular BKTPs remained in the same position as observed the normal beats. The early appearance of epicardial wavefronts in the basal region and generally in other areas of the right ventricle was attributed to the rapid propagation of excitation waves through the Purkinje network, probably associated to a short transmural crossing time, due to a local thinness of the ventricular wall.

摘要

先前关于兴奋在犬心室表面传播的研究使我们能够定位多达30个兴奋到达心室表面的突破点(BKTPs)。特别是等电位轮廓图使我们能够在右心室前表面靠近房室沟处检测到3至5个BKTPs,此时心室表面的大部分仍处于静息状态。为了研究这些基底区域早期兴奋的潜在机制,我们在几个右心室BKTPs以及与BKTPs有一定距离的其他点刺激心脏。瞬时等电位图显示,刺激后大多数右心室BKTPs保持与正常搏动时观察到的相同位置。心外膜波阵面在基底区域以及通常在右心室其他区域的早期出现归因于兴奋波通过浦肯野网络的快速传播,这可能与较短的跨壁穿越时间有关,这是由于心室壁局部变薄所致。

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引用本文的文献

1
Epicardial and intramural excitation during ventricular pacing: effect of myocardial structure.心室起搏时的心外膜和心壁内兴奋:心肌结构的影响
Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1753-66. doi: 10.1152/ajpheart.01400.2007. Epub 2008 Feb 8.