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英国的印巴移民个体饮食成分与安替比林代谢之间的关系。

The relationship between individual dietary constituents and antipyrine metabolism in Indo-Pakistani immigrants to Britain.

作者信息

Mucklow J C, Caraher M T, Henderson D B, Chapman P H, Roberts D F, Rawlins M D

出版信息

Br J Clin Pharmacol. 1982 Apr;13(4):481-6. doi: 10.1111/j.1365-2125.1982.tb01408.x.

Abstract

1 Antipyrine clearance has been measured from serial saliva samples in 36 healthy adult Indo-Pakistani immigrants to Britain, to assess the effect of dietary differences within this population. 2 Clearance (mean +/- s.e. mean) was significantly slower in 16 lactovegetarians (0.54 +/- 0.06 ml min -1 kg -1) than in the subjects who ate meat regularly (0.91 +/-0.07 ml min -1 kg -1). 3 The absence of meat from the diet was associated with a significantly smaller daily intake of dietary protein, which was abnormally low by Western standards. 4 It is likely that the contrast in daily protein intake between the dietary subgroups was largely responsible for the differences observed in antipyrine clearance.

摘要
  1. 为评估饮食差异对这一群体的影响,已对36名健康的成年印巴裔英国移民连续采集唾液样本,测量了安替比林清除率。2. 16名乳类素食者的清除率(均值±标准误)(0.54±0.06毫升/分钟·千克-1)显著慢于经常吃肉的受试者(0.91±0.07毫升/分钟·千克-1)。3. 饮食中不含肉类与每日膳食蛋白质摄入量显著减少有关,按西方标准这一摄入量异常低。4. 饮食亚组之间每日蛋白质摄入量的差异很可能是安替比林清除率观察到差异的主要原因。

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引用本文的文献

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本文引用的文献

1
Drug metabolism in white vegetarians.白种素食者的药物代谢
Br J Clin Pharmacol. 1980 May;9(5):523-5. doi: 10.1111/j.1365-2125.1980.tb05853.x.
2
The influence of changes in dietary fat on the clearance of antipyrine and 4-hydroxylation of debrisoquine.
Br J Clin Pharmacol. 1980 Mar;9(3):283P. doi: 10.1111/j.1365-2125.1980.tb04843.x.
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Effect of age and sex on human drug metabolism.年龄和性别对人体药物代谢的影响。
Br Med J. 1971 Sep 11;3(5775):607-9. doi: 10.1136/bmj.3.5775.607.
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Red cell enzyme polymorphisms in Punjabis in North India.印度北部旁遮普人的红细胞酶多态性。
Am J Phys Anthropol. 1972 Sep;37(2):293-9. doi: 10.1002/ajpa.1330370215.
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Rapid gas-liquid chromatographic estimation of antipyrine in plasma.血浆中安替比林的快速气-液色谱法测定
J Pharm Pharmacol. 1973 Mar;25(3):205-7. doi: 10.1111/j.2042-7158.1973.tb10625.x.
9
Enhanced drug metabolism in cigarette smokers.吸烟者体内药物代谢增强。
Br Med J. 1976 Jul 17;2(6028):147-9. doi: 10.1136/bmj.2.6028.147.

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