Roediger W E, Heyworth M, Willoughby P, Piris J, Moore A, Truelove S C
J Clin Pathol. 1982 Mar;35(3):323-6. doi: 10.1136/jcp.35.3.323.
Luminal concentrations of short chain fatty acids (SCFA), ammonia, sodium and potassium were measured in colonic dialysate of 16 control subjects and in 65 cases with ulcerative colitis (UC), which were graded according to mucosal changes into mild (1), moderate (2), or severe (3) inflammatory activity. Sodium concentrations were mildly but not significantly increased in severe ulcerative colitis while luminal potassium concentrations were markedly decreased in severe ulcerative colitis (p less than 0.025). Concentrations of SCFA were increased in severe ulcerative colitis. Butyrate concentrations were significantly raised in all stages of active ulcerative colitis even when other fatty acids were not raised. Of all the parameters a lowered pH and raised butyrate concentration most strikingly correlate with the severity of mucosal change. Results indirectly suggest that control of luminal pH, potassium secretion and utilisation of butyrate by the colonic mucosa are impaired with progressive mucosal inflammation.
对16名对照受试者以及65例溃疡性结肠炎（UC）患者的结肠透析液中的短链脂肪酸（SCFA）、氨、钠和钾的管腔浓度进行了测量，这些溃疡性结肠炎患者根据黏膜变化分为轻度（1级）、中度（2级）或重度（3级）炎症活动。在重度溃疡性结肠炎中，钠浓度有轻度升高，但无显著差异，而在重度溃疡性结肠炎中管腔钾浓度显著降低（p<0.025）。重度溃疡性结肠炎中SCFA浓度升高。即使其他脂肪酸未升高，在活动性溃疡性结肠炎的所有阶段丁酸盐浓度均显著升高。在所有参数中，pH降低和丁酸盐浓度升高与黏膜变化的严重程度最显著相关。结果间接表明，随着黏膜炎症的进展，结肠黏膜对管腔pH的控制、钾分泌以及丁酸盐的利用均受到损害。
