Blazheevich N V, Spirichev V B, Ushakov A S, Belakovskiĭ M S, Pozdniakova A L
Kosm Biol Aviakosm Med. 1982 Mar-Apr;16(2):34-40.
The exposure of rats to hypokinesia and a phosphorus-enriched diet (Ca : P = 1:3) was accompanied by hypocalciemia, hyperphosphatemia, calcium losses from bones and formation of calcificates in the kidneys. The decrease of the phosphorus content in the diet (Ca : P = 1:0.5--1:1) prevented these disorders. The administration of 1 alpha OHD3 at a dose of 0.025 microgram/day arrested hypokinesia-associated hypocalciemia and bone changes. The administration of 1 alpha OHD3 together with a high phosphorus consumption enhanced nephrolithiasis and induced aortal mediacalcinosis in hypokinetic rats. These data indicate that phosphorus consumption should be reduced in order to prevent disorders in phosphorus-calcium metabolism during hypokinesia. They also suggest that administration of 1 alpha OHD3 may be hazardous in case of excessive phosphorus consumption.
将大鼠暴露于运动不足和高磷饮食（钙：磷 = 1:3）环境中，会伴随低钙血症、高磷血症、骨质钙流失以及肾脏中形成钙化。饮食中磷含量的降低（钙：磷 = 1:0.5 - 1:1）可预防这些紊乱。以每天0.025微克的剂量给予1α-骨化三醇可阻止与运动不足相关的低钙血症和骨骼变化。在运动不足的大鼠中，同时给予1α-骨化三醇和高磷饮食会加重肾结石形成并诱发主动脉中层钙化。这些数据表明，为预防运动不足期间磷钙代谢紊乱，应减少磷的摄入量。它们还提示，在磷摄入过量的情况下，给予1α-骨化三醇可能具有危险性。
