Mortensen B T, Bojsen J
J Biomed Eng. 1982 Apr;4(2):103-6. doi: 10.1016/0141-5425(82)90069-3.
Platinum is considered to be a noble metal and is often used for electrodes in biological investigations. However, platinum electrodes can form inhibitory compounds, as pointed out by Rosenberg et al. 1965. The aim of this study was to investigate whether platinum electrodes are inert in the extremely low frequency (ELF) range of currents. Human bone marrow cells cultured in agar were used as target cells and were grown under various electrical conditions. A 50% reduction in growth compared with controls was obtained by average currents of 2300 microA at 8 Hz and 110 microA at 80 Hz, the current being derived from a square bipolar voltage waveform. D.c. currents were also inhibitory, with a value of 50% at the 1.4 microA level. The cells were probably not affected directly by the current, since inhibitory properties could be stored in agar and saline and because titanium electrodes at equal current levels did not produce the same effect.
铂被认为是一种贵金属，常用于生物学研究中的电极。然而，正如罗森伯格等人在1965年所指出的，铂电极会形成抑制性化合物。本研究的目的是调查铂电极在极低频（ELF）电流范围内是否呈惰性。在琼脂中培养的人类骨髓细胞被用作靶细胞，并在各种电条件下生长。通过8Hz时平均电流为2300微安和80Hz时平均电流为110微安（电流源自方形双极电压波形），与对照组相比，细胞生长减少了50%。直流电流也具有抑制作用，在1.4微安水平时抑制率为50%。细胞可能不是直接受到电流影响，因为抑制特性可以存储在琼脂和盐水中，并且因为在相同电流水平下钛电极不会产生相同的效果。
