Hai N P
J Pharmacol Methods. 1982 Jan;7(1):57-64. doi: 10.1016/0160-5402(82)90058-4.
A method for the implantation of catheters into carotid, jugular, and femoral vessels that allows long-term access in conscious dogs has been described. The vascular catheters, especially when introduced into the femoral vessels, remain patent for more than 12 months. This improved patency may result from the solving of several methodological problems: 1. firm securing of the catheters to the vessels with a simple polyethylene perivascular muff that is rapidly prepared and introduced; 2. a 5 cm long replaceable catheter connected to the free end of the intravascular tubing prevents the need to replace the entire implantation after crushing; 3. a leather jacket, together with a large leather collar in some cases, prevents the animal from damaging the free ends of the catheters that lie longitudinally along the back. In addition, they allow rapid healing of the incisions, particularly in the thigh.
已经描述了一种将导管植入颈动脉、颈静脉和股血管的方法，该方法可使清醒犬获得长期通路。血管导管，尤其是引入股血管时，可保持通畅超过12个月。这种改善的通畅性可能源于几个方法学问题的解决：1. 使用快速制备和引入的简单聚乙烯血管周围套管将导管牢固固定在血管上；2. 连接到血管内管道自由端的5厘米长可更换导管避免了在受压后需要更换整个植入物；3. 在某些情况下，皮夹克以及大皮项圈可防止动物损坏沿背部纵向放置的导管自由端。此外，它们可使切口快速愈合，尤其是在大腿处。
