亚油酸在多发性硬化症中的应用：未显示出任何治疗益处。

Linoleic acid in multiple sclerosis: failure to show any therapeutic benefit.

作者信息

Paty D W, Cousin H K, Read S, Adlakha K

出版信息

Acta Neurol Scand. 1978 Jul;58(1):53-8. doi: 10.1111/j.1600-0404.1978.tb02859.x.

DOI:10.1111/j.1600-0404.1978.tb02859.x

Abstract

We have studied the effect of a dietary supplement with linoleic acid (LA) in 76 patients with MS. We could detect no effect of this supplement on the progression of neurological findings, the relapse rate, or the severity of relapses. We were also able to show that oral supplementation with a linoleic acid preparation would raise the blood level of LA in these patients. We were unable to show that there was any reduction in the linoleic acid blood levels associated with acute relapses of MS during this study.

摘要

我们研究了在76例多发性硬化症（MS）患者中使用含亚油酸（LA）的膳食补充剂的效果。我们未检测到该补充剂对神经学表现的进展、复发率或复发严重程度有任何影响。我们还能够证明，口服亚油酸制剂会提高这些患者的血液中亚油酸水平。在本研究中，我们未能证明与MS急性复发相关的血液中亚油酸水平有任何降低。