一项关于自发姐妹染色单体交换频率的家族研究。
A family study of spontaneous sister chromatid exchange frequency.
作者信息
Cohen M M, Martin A O, Ober C, Simpson S J
出版信息
Am J Hum Genet. 1982 Mar;34(2):294-306.
The frequency of spontaneous sister chromatid exchanges (SCEs) was determined in PHA-stimulated peripheral lymphocytes of 52 individuals, comprising 12 complete 2-generation pedigrees. Neither intraindividual variation between replicate cultures established from the same blood sample nor variation among samples from the same individual initiated at different times was significant. However, familial factors affecting mean SCE frequencies were indicated by detection of significant differences among, but not within, families. Although sample sizes were small, a genetic contribution to the SCE frequency was suggested by the observed pattern of familial correlations.
在52名个体（包括12个完整的两代家系）经PHA刺激的外周淋巴细胞中测定了自发姐妹染色单体交换（SCE）的频率。来自同一份血样的重复培养物之间的个体内变异以及在不同时间采集的来自同一个体的样本之间的变异均无显著意义。然而，通过检测家系间（而非家系内）的显著差异表明存在影响平均SCE频率的家族因素。尽管样本量较小，但观察到的家族相关性模式提示SCE频率存在遗传因素的作用。
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