单剂量甲氧苄啶-磺胺甲恶唑治疗有症状的泌尿系统感染。
Single dose trimethoprim-sulphamethoxazole treatment of symptomatic urinary infection.
作者信息
Pitt W R, Dyer S A, McNee J L, Burke J R
出版信息
Arch Dis Child. 1982 Mar;57(3):229-31. doi: 10.1136/adc.57.3.229.
Seventy-nine children with symptoms of urinary tract infections were randomly allocated to treatment with a single dose or a 7-day course of trimethoprim-sulphamethoxazole. Of the 42 patients (39 girls, 3 boys) who fulfilled the criteria for the trial, 23 were given a single-dose regimen and 19 of them a 7-day regimen. Both groups of patients had sterile urine cultures 2 days after starting treatment. Eight patients had underlying structural renal abnormalities (n = 3, single-dose regimen; n = 5, 7-day regimen). One patient in the single dose group had a recurrence of infection on day 7. These results show that single dose trimethoprim-sulphamethoxazole is as effective as the conventional 7-day course in children with symptomatic urinary tract infection. Further investigation of the renal tract is necessary regardless of the fact that the infection has been eradicated by single-dose treatment.
79名有尿路感染症状的儿童被随机分配接受单剂量或7天疗程的甲氧苄啶-磺胺甲恶唑治疗。在符合试验标准的42例患者（39名女孩，3名男孩）中，23例接受单剂量方案，其中19例接受7天疗程方案。两组患者在开始治疗2天后尿培养均无菌。8例患者有潜在的肾脏结构异常（单剂量方案组3例；7天疗程方案组5例）。单剂量组有1例患者在第7天感染复发。这些结果表明，单剂量甲氧苄啶-磺胺甲恶唑在有症状的儿童尿路感染中与传统的7天疗程同样有效。无论单剂量治疗是否已根除感染，对尿路进行进一步检查都是必要的。
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