Ruppanner R, Brooks D, Franti C E, Behymer D E, Morrish D, Spinelli J
Arch Environ Health. 1982 Mar-Apr;37(2):103-10. doi: 10.1080/00039896.1982.10667545.
Two recent outbreaks of Q fever in research institutions prompted the authors to review extant data, in an effort to delineate hazards to humans from small ruminants used in research. Prevalence of Q fever antibodies was 24% among 2097 sheep and 57% among 1475 goats from various sources. In a facility using sheep for prenatal research, in which an epidemic of human Q fever later occurred, antibody prevalence among sheep was 77%, with larger than usual proportions of high (greater than or equal to 128) titers. Antibody prevalence was 5% in a sample from the general human population and 11% among 347 persons at three research institutions (17% among students, 8% among the research staff). Except for animal caretakers routinely exposed to sheep, antibody prevalence among research staff approximated prevalence in the general population. Suggestions are made for surveillance and vaccination of sheep and goats used in medical research institutions.
近期研究机构中发生的两起Q热疫情促使作者回顾现有数据，以确定用于研究的小型反刍动物对人类的危害。在来自不同来源的2097只绵羊中，Q热抗体阳性率为24%，在1475只山羊中为57%。在一个使用绵羊进行产前研究的机构中，后来发生了人类Q热疫情，绵羊中的抗体阳性率为77%，高（大于或等于128）滴度的比例高于正常水平。一般人群样本中的抗体阳性率为5%，三个研究机构的347人中为11%（学生中为17%，研究人员中为8%）。除了经常接触绵羊的动物饲养员外，研究人员中的抗体阳性率接近一般人群中的阳性率。文中针对医学研究机构中使用的绵羊和山羊的监测与疫苗接种提出了建议。
