Simor A E, Brunton J L, Salit I E, Vellend H, Ford-Jones L, Spence L P
Can Med Assoc J. 1984 Apr 15;130(8):1013-6.
The recent recognition that Q fever is endemic in Ontario and the known occupational risk of Q fever to research personnel working with sheep prompted a study to determine the prevalence of antibodies to the causative organism, Coxiella burnetti, in animals and staff at a Toronto animal research institute. Of 37 sheep 34 (92%) were found to be seropositive--that is, to have a titre of complement-fixing antibody to the phase II antigen of 1:8 or greater. Of 331 staff members tested, 18% were found to be seropositive, compared with 0.6% of a random sample of Toronto blood donors. The highest rate of seropositivity, 68%, was in the 28 animal attendants tested. Seropositivity was associated with working with sheep or fetal lamb tissue (p less than 0.0001) and with visiting the animal facility (p less than 0.001). Of the 59 seropositive staff members 63% had had no direct contact with sheep. There were 12 clinically apparent cases of Q fever, 2 of which required admission to hospital. Q fever remains a serious occupational hazard to staff working in research laboratories using sheep, even to those with indirect exposure to infected animals.
最近认识到Q热在安大略省呈地方性流行，且已知从事羊研究工作的研究人员面临Q热职业风险，这促使开展一项研究，以确定多伦多一家动物研究机构的动物和工作人员中针对病原体伯氏考克斯体的抗体流行情况。在37只羊中，发现34只（92%）血清呈阳性，即针对II期抗原的补体结合抗体滴度为1:8或更高。在接受检测的331名工作人员中，18%血清呈阳性，而多伦多献血者随机样本的这一比例为0.6%。血清阳性率最高的是接受检测的28名动物饲养员，为68%。血清阳性与接触羊或胎羊组织（p<0.0001）以及进入动物设施（p<0.001）有关。在59名血清呈阳性的工作人员中，63%未曾直接接触过羊。有12例临床明显的Q热病例，其中2例需要住院治疗。对于在使用羊的研究实验室工作的人员，即使是那些间接接触感染动物的人员，Q热仍然是一种严重的职业危害。
