Heppell L M, Kilshaw P J
Int Arch Allergy Appl Immunol. 1982;68(1):54-9. doi: 10.1159/000233067.
Introduction of ovalbumin into the diet of guinea pigs initially evoked the production of circulating antibody. With continued feeding, antibody levels declined in animals fed with ovalbumin from 2-4 days or 6-8 weeks of age, but remained constant in guinea pigs commencing the feeding regimen at 5-6 months of age. All animals receiving dietary ovalbumin became hyporesponsive to parenteral injection with ovalbumin in adjuvant, and suppression of IgG1 and IgG2 antibody subclasses was observed. The results demonstrated that delayed hypersensitivity to ovalbumin was more readily suppressed by the feeding regimen than the systemic antibody response.
将卵清蛋白引入豚鼠饮食中最初会引发循环抗体的产生。持续喂食后，2 - 4日龄或6 - 8周龄开始喂食卵清蛋白的动物体内抗体水平下降，但5 - 6月龄开始喂食方案的豚鼠体内抗体水平保持恒定。所有接受饮食中卵清蛋白的动物对卵清蛋白与佐剂的皮下注射均变得反应低下，并观察到IgG1和IgG2抗体亚类受到抑制。结果表明，与全身抗体反应相比，喂食方案更容易抑制对卵清蛋白的迟发型超敏反应。
