Saarikoski S, Kivalo I, Pispa J
Int J Biol Res Pregnancy. 1982;3(1):18-20.
The maternal and fetal sympathoadrenal system was studied by radioenzymatic measurement of the release of NA and A in 20 women with full-term uncomplicated pregnancies at cesarean section. Atropinization was performed 30 min or immediately before the induction of anesthesia. Before induction the mean level of maternal plasma NA in the i.v. atropinization group was 1.9 +/- 0.3 pmol/ml and in the i.m. group, 1.2 +/- 0.2 pmol/ml (mean +/- SE) (p greater than 0.05), and the levels of plasma A were 0.5 +/- 0.2 and 0.2 +/- 0.1 pmol/ml, respectively (p greater than 0.05). No significant rise was observed to be connected with the induction of anesthesia. Fetal umbilical arterial NA and A concentrations were higher than maternal values. CA concentration measured in the umbilical artery was 3-6 times higher than the corresponding values measured in the umbilical vein, indicating metabolization of CA in the placenta. Individual variation of fetal NA and A was very high, suggesting great individual alterations in the activity of the fetal sympathoadrenal system.
通过放射酶法测定20例足月无并发症妊娠行剖宫产术产妇的去甲肾上腺素（NA）和肾上腺素（A）释放量，对母婴交感肾上腺系统进行了研究。在诱导麻醉前30分钟或即刻进行阿托品化。诱导前，静脉注射阿托品化组产妇血浆NA的平均水平为1.9±0.3 pmol/ml，肌肉注射组为1.2±0.2 pmol/ml（平均值±标准误）（p>0.05），血浆A水平分别为0.5±0.2和0.2±0.1 pmol/ml（p>0.05）。未观察到与麻醉诱导相关的显著升高。胎儿脐动脉NA和A浓度高于母体值。脐动脉中测得的儿茶酚胺（CA）浓度比脐静脉中测得的相应值高3 - 6倍，表明胎盘对CA有代谢作用。胎儿NA和A的个体差异非常大，提示胎儿交感肾上腺系统的活性存在很大的个体差异。
