Sikora K
J Clin Pathol. 1982 Apr;35(4):369-75. doi: 10.1136/jcp.35.4.369.
Molecular biology has made tremendous strides over the last five years. The new biology allows us to prepare monoclonal antibodies to defined antigens; to detect, isolate and clone specific genes; and to insert these genes into defined sites in different cells giving new functions to old organisms. These revolutionary developments have been followed closely by researchers, businessmen, politicians and philosophers, as well as by those involved in the clinical care of patients. Although our understanding of human molecular biology is increasing rapidly, it is the development of monoclonal antibodies that has the most immediate application in the clinic. There have been several reports of their use in the diagnosis, localisation and treatment of human malignant disease. This review describes developments that are likely to have direct relevance to patient care in the near future.
在过去五年中，分子生物学取得了巨大进展。新生物学使我们能够制备针对特定抗原的单克隆抗体；检测、分离和克隆特定基因；并将这些基因插入不同细胞的特定位点，赋予古老生物体新功能。这些革命性的进展受到了研究人员、商人、政治家、哲学家以及参与患者临床护理的人员的密切关注。尽管我们对人类分子生物学的理解正在迅速增加，但单克隆抗体的发展在临床上具有最直接的应用。已有多篇关于其在人类恶性疾病诊断、定位和治疗中的应用报道。本综述描述了在不久的将来可能与患者护理直接相关的进展。
