Makin C A
Ann R Coll Surg Engl. 1986 Nov;68(6):298-301.
The search for tumour markers was intensified with the advent of monoclonal antibody technology. To date no tumour specific markers have been found. Despite this, monoclonal antibodies have helped to identify cells in terms of their origin and function and therefore added a different dimension to studies of both benign and malignant disease processes. Advances in molecular biology have made cooperation between scientists and clinicians in all branches of medicine essential in order to piece together a more complete picture of any disease. This article describes the production and characterisation of two epithelial specific monoclonal antibodies (CAM5.2 and CAM17.1) with potential clinical value by a surgeon temporarily transposed to a laboratory environment.
随着单克隆抗体技术的出现，对肿瘤标志物的研究力度加大。迄今为止，尚未发现肿瘤特异性标志物。尽管如此，单克隆抗体有助于根据细胞的起源和功能对其进行识别，从而为良性和恶性疾病过程的研究增添了一个不同的维度。分子生物学的进展使得医学各分支领域的科学家和临床医生之间的合作变得至关重要，以便拼凑出任何疾病更完整的图景。本文描述了一位临时转入实验室环境的外科医生制备并鉴定的两种具有潜在临床价值的上皮特异性单克隆抗体（CAM5.2和CAM17.1）。
