deShazo R D, Hase T, Wright D G, Diem J E
J Allergy Clin Immunol. 1982 May;69(5):429-34. doi: 10.1016/0091-6749(82)90117-8.
Leukocyte chemotaxis was studied in 11 patients with severe childhood onset atopic dermatitis at a time when their disease was relatively quiescent. Pyoderma had been an important complication of the dermatitis in these patients. The chemotactic responsiveness of patient neutrophils and monocytes was on the average not significantly different from that of healthy control subjects, although three patients were identified who had significantly impaired responses. No correlation between IgE levels and leukocyte chemotaxis was observed. Because excessive amounts of histamine have been recovered from the skin of patients with atopic dermatitis, we evaluated the effects of histamine on the chemotactic responsiveness of leukocytes from these patients. Histamine caused a small dose-related increase in chemotaxis of neutrophils from both patients and control subjects (10(-7)M to 10(-5)M histamine). In contrast, histamine had no effect on the chemotaxis of monocytes from control subjects but inhibited the chemotactic responsiveness of monocytes from atopic dermatitis patients. These findings suggest that an abnormal sensitivity of monocytes to histamine is an intrinsic feature of atopic dermatitis that may be detectable when the disease is quiescent. Furthermore, this abnormality may contribute to the impairment of monocyte chemotaxis that has been previously observed in patients with active atopic dermatitis.
在11例儿童期起病的重度特应性皮炎患者病情相对静止时，对其白细胞趋化性进行了研究。脓疱病是这些患者皮炎的重要并发症。患者中性粒细胞和单核细胞的趋化反应性平均与健康对照者无显著差异，不过有3例患者的反应明显受损。未观察到IgE水平与白细胞趋化性之间存在相关性。由于已从特应性皮炎患者的皮肤中检测到过量组胺，因此我们评估了组胺对这些患者白细胞趋化反应性的影响。组胺使患者和对照者中性粒细胞的趋化性呈小剂量相关增加（组胺浓度从10⁻⁷M至10⁻⁵M）。相比之下，组胺对对照者单核细胞的趋化性无影响，但抑制了特应性皮炎患者单核细胞的趋化反应性。这些发现表明，单核细胞对组胺的异常敏感性是特应性皮炎的一个内在特征，在疾病静止期可能检测到。此外，这种异常可能导致先前在活动期特应性皮炎患者中观察到的单核细胞趋化性受损。
