Lahti A, Hannuksela M
Allergy. 1978 Jun;33(3):143-6. doi: 10.1111/j.1398-9995.1978.tb01524.x.
Hypersensitivity to birch pollen was linked with allergy to apple and carrot, apple seeds and carrot seeds and also with their fractions. Skin reactions among other atopics were rare, and non-atopic patients showed no reactions to fresh fruits and vegetables. Apple and carrot as well as apple seeds and carrot seeds were fractionated using column chromatography. Two major fractions were obtained, one with sugar and proteins, and one with proteins, the latter giving skin reactions more often than the former. The correlation between clinical symptoms and skin test results with the fractionated material was somewhat lower than that obtained with the non-fractionated fresh material. The allergens of fruits and vegetables might be proteins (enzymes).
桦树花粉过敏与对苹果、胡萝卜、苹果籽和胡萝卜籽及其组分的过敏有关。其他特应性个体的皮肤反应很少见，非特应性患者对新鲜水果和蔬菜无反应。使用柱色谱法对苹果、胡萝卜以及苹果籽和胡萝卜籽进行分离。得到了两个主要组分，一个含有糖和蛋白质，另一个只含蛋白质，后者比前者更常引起皮肤反应。分级分离材料的临床症状与皮肤试验结果之间的相关性略低于未分级的新鲜材料。水果和蔬菜的过敏原可能是蛋白质（酶）。
