Linn W S, Medway D A, Anzar U T, Valencia L M, Spier C E, Tsao F S, Fischer D A, Hackney J D
Am Rev Respir Dis. 1982 May;125(5):491-5. doi: 10.1164/arrd.1982.125.5.491.
Eleven generally healthy volunteer subjects were exposed daily to ozone at 0.47 ppm in an attempt to develop adaptation, then reexposed weekly to investigate the persistence of adaptation. Responses were assessed in terms of forced expiratory function and symptoms. Most subjects, when exposed 2 h daily for 4 days with intermittent exercise, developed adaptation as seen in previous studies. The adaptation was partly lost with a 4-day interval between successive exposures, and was more or less completely lost with a 7-day interval between exposures. One subject, who may have had a persistent low-grade respiratory infection, never adapted. Two others showed relatively little response in the initial daily exposures, but showed more severe responses at some point during the later weekly exposures. If these results are relevant to ambient oxidant pollution effects, adaptation may be of relatively little importance in a public-health sense, given that it may fail to develop or may be lost quickly in the absence of very frequent exposures.
11名大体健康的志愿者每天暴露于浓度为0.47 ppm的臭氧环境中以尝试产生适应性，然后每周再次暴露以研究适应性的持续性。通过用力呼气功能和症状来评估反应。如先前研究所示，大多数受试者在每天暴露2小时、持续4天并伴有间歇性运动的情况下产生了适应性。连续暴露之间间隔4天时，适应性部分丧失；暴露之间间隔7天时，适应性或多或少完全丧失。一名可能患有持续性轻度呼吸道感染的受试者从未产生适应性。另外两名受试者在最初的每日暴露中反应相对较小，但在随后的每周暴露中的某个时间点出现了更严重的反应。如果这些结果与环境氧化剂污染影响相关，那么从公共卫生角度来看，适应性可能相对不太重要，因为在没有非常频繁暴露的情况下，适应性可能无法产生或可能很快丧失。
