多巴胺对足月妊娠时人体子宫活动的影响。

Dopamine influence on human uterine activity at term pregnancy.

作者信息

Urban J, Radwan J, Laudański T, Akerlund M

出版信息

Br J Obstet Gynaecol. 1982 Jun;89(6):451-5. doi: 10.1111/j.1471-0528.1982.tb03635.x.

DOI:10.1111/j.1471-0528.1982.tb03635.x

Abstract

The influence of dopamine on uterine activity was studied by external tocography in women at the end of a normal pregnancy. In those who were not in labour dopamine infusion (2 micrograms min-1 kg-1 body weight) induced regular uterine contractions and with higher doses the response increased. For women in spontaneous labour, dopamine at a dose of 4 micrograms min-1 kg-1 caused a significant increase in the frequency of contraction, but in women receiving an oxytocin infusion, no further stimulation was seen. Dopamine did not have any noticeable effect on fetal heart rate, maternal pulse rate or blood pressure and no other general effects were observed.

摘要

通过外部宫缩图研究了多巴胺对正常妊娠末期女性子宫活动的影响。在未临产的女性中，静脉输注多巴胺（2微克·分钟⁻¹·千克⁻¹体重）可诱发规律的子宫收缩，且随着剂量增加反应增强。对于自然临产的女性，剂量为4微克·分钟⁻¹·千克⁻¹的多巴胺可使宫缩频率显著增加，但在静脉输注缩宫素的女性中，未观察到进一步的刺激作用。多巴胺对胎儿心率、母体脉搏率或血压没有任何明显影响，也未观察到其他全身性影响。