Santos T Q, Valdimarsson H
J Neuroimmunol. 1982 Jun;2(3-4):215-22. doi: 10.1016/0165-5728(82)90056-x.
Systemic antibody responses were compared in mice injected with antigens into the subarachnoid space (SAS) and into conventional sites. Introduction of T-dependent antigens into the SAS induced higher systemic antibody responses than injections into any other sites. This applied to both soluble and particulate antigens and was more apparent in secondary than in primary responses. The effect was not observed with a T-independent antigen and not consistently with high doses of sheep red blood cells (SRBC). It was concluded that the subarachnoid space is a highly efficient site for the induction of systemic antibody production, in particular to low amounts of T-dependent antigens.
将抗原注射到蛛网膜下腔（SAS）和传统部位的小鼠中，比较其全身抗体反应。将T细胞依赖性抗原引入SAS所诱导的全身抗体反应高于注射到任何其他部位。这适用于可溶性和颗粒性抗原，并且在二次反应中比在初次反应中更明显。对于T细胞非依赖性抗原未观察到这种效应，对于高剂量的绵羊红细胞（SRBC）也未始终观察到这种效应。得出的结论是，蛛网膜下腔是诱导全身抗体产生的高效部位，特别是对于少量的T细胞依赖性抗原。
