阿南定 A 和 B，两种来自海洋放线菌 Streptomyces anandii H41-59 的罕见甾体生物碱。
Anandins A and B, Two Rare Steroidal Alkaloids from a Marine Streptomyces anandii H41-59.
机构信息
Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Institute of Traditional Chinese Medicine and Natural Product, College of Pharmacy, Jinan University, Guangzhou 510632, China.
Key Laboratory of New Technique for Plant Protection in Guangdong, Institute of Plant Protection, Guangdong Academy of Agricultural Sciences, Guangzhou 510632, China.
出版信息
Mar Drugs. 2017 Nov 10;15(11):355. doi: 10.3390/md15110355.
Anandins A () and B (), two rare steroidal alkaloids, were isolated from the fermentative broth of a marine actinobacteria H41-59. The gross structures of the two alkaloids were elucidated by spectroscopic methods including HR-ESI-MS, and NMR. Their absolute configurations were confirmed by single-crystal X-ray diffraction analysis and comparison of their experimental and calculated electronic circular dichroism spectra, respectively. Anandin A exhibited a moderate inhibitory effect against three human cancer cell lines MCF-7, SF-268, and NCI-H460 with IC values of 7.5, 7.9, 7.8 μg/mL, respectively.
从海洋放线菌 H41-59 的发酵液中分离得到两种罕见的甾体生物碱：阿南定 A（）和 B（）。通过高分辨电喷雾质谱（HR-ESI-MS）和 NMR 等光谱方法阐明了这两种生物碱的结构。通过单晶 X 射线衍射分析和比较它们的实验和计算电子圆二色谱光谱分别确定了它们的绝对构型。阿南定 A 对三种人癌细胞系 MCF-7、SF-268 和 NCI-H460 表现出中等抑制作用，IC 值分别为 7.5、7.9 和 7.8μg/mL。
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