Buongiorno R, Dentico P, Santantonio T, Frappampina V, Spinelli A, Amato M, Pastore G
Boll Soc Ital Biol Sper. 1980 Oct 30;56(20):2076-82.
Sera of thirty-five hepatitis B surface antigen (HBsAg) positive hemodialysis patients and fifty-three asymptomatic HBsAg chronic carrier were studied to assess the relationship between markers of virus activity (hepatitis B e antigen and core-associated DNA polymerase activity) and titers of HBsAg and of antibody to hepatitis B core antigen (anti-HBc). All sera were tested by solid-phase radioimmunoassay methods. HBeAg was detected in 20 (51%) hemodialysis patients and in 14 (26%) asymptomatic carriers, whereas DNA P activity was present in sera of 21 (60%) and 17 (32%) respectively. The highest titers of HBsAg and anti-HBc expressed as P/N ratio between positive and negative controls, were detected in the majority of hemodialysis patients, whereas asymptomatic carriers showed low titers of these markers. These data suggest that in HBsAg positive hemodialysis patients a more active viral replication occurs and further underline the difference between these patients and other categories of HBsAg carriers in terms of infectivity.
对35例乙肝表面抗原（HBsAg）阳性的血液透析患者和53例无症状HBsAg慢性携带者的血清进行了研究，以评估病毒活性标志物（乙肝e抗原和核心相关DNA聚合酶活性）与HBsAg及乙肝核心抗原抗体（抗-HBc）滴度之间的关系。所有血清均采用固相放射免疫测定法检测。在20例（51%）血液透析患者和14例（26%）无症状携带者中检测到HBeAg，而DNA P活性分别在21例（60%）和17例（32%）的血清中存在。以阳性和阴性对照之间的P/N比值表示的HBsAg和抗-HBc的最高滴度，在大多数血液透析患者中被检测到，而无症状携带者则显示这些标志物的滴度较低。这些数据表明，在HBsAg阳性的血液透析患者中发生了更活跃的病毒复制，并进一步强调了这些患者与其他类别HBsAg携带者在传染性方面的差异。
