Sonnenberg A, Müller-Lissner S A, Schattenmann G, Siewert J R, Blum A L
Am J Physiol. 1982 Jun;242(6):G603-7. doi: 10.1152/ajpgi.1982.242.6.G603.
Duodenogastric reflux, gastric emptying, and gastric secretion were measured simultaneously by a double-marker technique after instillation of a liquid lipid meal (300 ml Intralipid) or a protein meal (300 ml Bactopeptone) in five trained mongrel dogs. A lipid meal was emptied slower and elicited less volume secretion than a protein meal. Duodenogastric reflux rate and intragastric accumulation of duodenal contents were similar with both meals. Intravenous infusion of atropine slowed gastric emptying and inhibited gastric volume secretion only in the case of protein meal. Atropine increased duodenogastric reflux rate and gastric accumulation of duodenal contents with both protein and lipid meals. The percentage of duodenal contents inside the stomach increased continuously during gastric emptying; it did not exceed 20% with both meals given alone and 40% with both meals given together with atropine. It is concluded that duodenogastric reflux and gastric accumulation of duodenal contents are common phenomena during gastric digestion of a meal. The degree of such accumulation does not depend on the type of meal. Intragastric accumulation of duodenal contents is increased when duodenogastric reflux rate is stimulated and when gastric emptying rate is inhibited simultaneously.
在五只经过训练的杂种犬中，通过双标记技术在给予液体脂质餐（300ml英脱利匹特）或蛋白质餐（300ml细菌蛋白胨）后，同时测量十二指肠-胃反流、胃排空和胃分泌。脂质餐的排空比蛋白质餐慢，引起的容量分泌也较少。两种餐的十二指肠-胃反流率和十二指肠内容物在胃内的积聚相似。静脉注射阿托品仅在蛋白质餐的情况下减慢胃排空并抑制胃容量分泌。阿托品增加了蛋白质餐和脂质餐的十二指肠-胃反流率以及十二指肠内容物在胃内的积聚。在胃排空过程中，胃内十二指肠内容物的百分比持续增加；单独给予两种餐时不超过20%，与阿托品一起给予两种餐时不超过40%。结论是，十二指肠-胃反流和十二指肠内容物在胃内的积聚是进餐时胃消化过程中的常见现象。这种积聚的程度不取决于餐的类型。当十二指肠-胃反流率受到刺激且胃排空率同时受到抑制时，十二指肠内容物在胃内的积聚增加。
