Berry P H, Vogel P
Aust J Exp Biol Med Sci. 1982 Feb;60(Pt 1):129-32. doi: 10.1038/icb.1982.13.
Estimates of the LD50's of 7 glycolipid toxins (corynetoxins) isolated from toxic annual ryegrass varied in the range 0 . 1-1 . 3 mg/kg in 2-week-old rats. The delay in onset of neurological signs in rats and sheep was independent of dose rate and could be the result of inhibition of protein biosynthesis. In sheep, no influence of the route of administration on the delay in onset of neurological signs was demonstrated. The relationship between the partial structures of the two major corynetoxins and their toxicity is discussed.
从有毒一年生黑麦草中分离出的7种糖脂毒素（棒杆菌毒素）对2周龄大鼠的半数致死剂量（LD50）估计值在0.1 - 1.3毫克/千克范围内。大鼠和绵羊出现神经症状的延迟与剂量率无关，可能是蛋白质生物合成受到抑制的结果。在绵羊中，未证明给药途径对神经症状出现延迟有影响。文中讨论了两种主要棒杆菌毒素的部分结构与其毒性之间的关系。
