Moore S A, Peterson R G, Felten D L, O'Connor B L
J Neurol Sci. 1981 Nov-Dec;52(2-3):289-303. doi: 10.1016/0022-510x(81)90012-5.
Tibial nerves of streptozotocin-diabetic, alloxan-diabetic, and age-matched control rats were examined at 2 weeks and 2, 4, 8, and 12 months following the induction of diabetes. Glycogen-like granules accumulated within perineurial and Schwann cells of only the diabetic animals. This accumulation may reflect a metabolic abnormality in these cells which could account for the reduced conduction velocities seen in the peripheral nerves of these same diabetic rats (Moore et al. 1980a). Glycogen-like granules were also present and increased with age in myelinated axons of both diabetic and control rats. Quantitative data suggest that axonal accumulation of glycogen-like granules is related to aging or injury related phenomena to which diabetic axons may be more susceptible.
在糖尿病诱导后的2周以及2、4、8和12个月，对链脲佐菌素诱导糖尿病的大鼠、四氧嘧啶诱导糖尿病的大鼠以及年龄匹配的对照大鼠的胫神经进行了检查。仅在糖尿病动物的神经束膜细胞和施万细胞内积累了糖原样颗粒。这种积累可能反映了这些细胞中的代谢异常，这可能是这些相同糖尿病大鼠外周神经传导速度降低的原因（Moore等人，1980a）。在糖尿病大鼠和对照大鼠的有髓轴突中也存在糖原样颗粒，并且随着年龄的增长而增加。定量数据表明，糖原样颗粒的轴突积累与衰老或损伤相关现象有关，而糖尿病轴突可能对这些现象更敏感。
