Goldstein D J, Barr R J, Santa Cruz D J
Cancer. 1982 Aug 1;50(3):566-72. doi: 10.1002/1097-0142(19820801)50:3<566::aid-cncr2820500330>3.0.co;2-q.
Microcystic adnexal carcinoma is an unusual locally aggressive neoplasm that is important to recognize since it may be confused with benign adnexal neoplasms, particularly desmoplastic trichoepithelioma, trichoadenoma, and syringoma. Six cases are described all of which displayed benign histological features on initial biopsy. Most often these neoplasms presented as solitary flesh-colored indurated plaques on the upper lip. All patients were white, five were women, and the average age was 44-years-old. Islands of basaloid keratinocytes, some of which contained horn cysts and abortive follicles, were embedded in a desmoplastic stroma. In other foci, ducts and gland-like structures lined by a two-cell layer predominated. In deep components individual and thin strands of cells dissected collagen bundles and skeletal muscle and invaded perineural spaces. Despite this, cytologic atypia and mitotic figures were rare. The cell of origin is considered to be a pluripotential adnexal keratinocyte which is capable of both follicular and sweat gland differentiation.
微囊性附属器癌是一种不常见的具有局部侵袭性的肿瘤，因其可能与良性附属器肿瘤，特别是促结缔组织增生性毛发上皮瘤、毛发腺瘤和汗管瘤相混淆，所以识别它很重要。本文描述了6例病例，所有病例在初次活检时均表现出良性组织学特征。这些肿瘤最常表现为上唇的孤立性肉色硬结斑块。所有患者均为白人，5例为女性，平均年龄44岁。基底样角质形成细胞岛，其中一些含有角囊肿和发育不全的毛囊，嵌入促结缔组织增生性基质中。在其他病灶中，以由两层细胞衬里的导管和腺样结构为主。在深部成分中，单个的细细胞条索分离胶原束和骨骼肌并侵犯神经周间隙。尽管如此，细胞学异型性和有丝分裂象很少见。其起源细胞被认为是一种多能性附属器角质形成细胞，能够进行毛囊和汗腺分化。
