Antoniades K, Spector H
Cancer. 1982 Aug 15;50(4):793-6. doi: 10.1002/1097-0142(19820815)50:4<793::aid-cncr2820500429>3.0.co;2-o.
Quantitative estrogen receptor (ER) values in patients with breast carcinoma were correlated with the natural history of the disease before surgical intervention. The natural history was expressed as an index of growth. This was determined as a ratio between tumor size (centimeters) and duration of symptoms (weeks). An inverse correlation was found between amount of ER and growth. Tumors with high positive (above 101 fmol/mg/protein) ER values has grown significantly slower (P less than 0.05) than tumors with low positive (below 50 fmol/mg protein) or negative ER values. These two latter groups had a similar natural history. Recognition of the fact that there is slow growth in carcinomas with high ER as well as of the fact that growth is as rapid in carcinomas with low ER levels as it is in carcinomas with negative ER values, demonstrates the importance of quantitative ER determinations, their prognostic value, and their usefulness in planning therapy.
乳腺癌患者的雌激素受体（ER）定量值与手术干预前疾病的自然史相关。自然史以生长指数表示。这被确定为肿瘤大小（厘米）与症状持续时间（周）之间的比率。发现ER量与生长之间呈负相关。ER值高阳性（高于101 fmol/mg/蛋白质）的肿瘤生长明显慢于ER值低阳性（低于50 fmol/mg蛋白质）或ER值阴性的肿瘤（P小于0.05）。后两组具有相似的自然史。认识到ER高的癌生长缓慢以及ER水平低的癌与ER值阴性的癌生长一样快这一事实，证明了ER定量测定的重要性、其预后价值及其在治疗计划中的有用性。
