烟酰胺腺嘌呤二核苷酸（NAD⁺）依赖性前列腺素脱氢酶活性在人胎儿组织中的分布。

Distribution of NAD+-dependent prostaglandin dehydrogenase activity among human fetal tissues.

作者信息

Casey M L, Johnston J M, MacDonald P C

出版信息

Early Hum Dev. 1982 Apr;6(2):171-5. doi: 10.1016/0378-3782(82)90105-0.

Abstract

In the present investigation the activity of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase was measured in the cytosolic fractions prepared from various tissues of the human fetus. Among the different tissues studied the specific activity of this enzyme varied widely. The specific activities of prostaglandin dehydrogenase were greatest in the adrenal gland, placenta, and ureter, while moderate levels were found in kidney, lung, and testis; low or undetected levels were found in other tissues including heart, intestine, and brain. The finding of wide variations in the specific activity of prostaglandin dehydrogenase among tissues of the human fetus is supportive of the possibility that this enzyme has an important role in the regulation of the levels of prostaglandins in these tissues.

摘要

在本研究中，测定了从人类胎儿的各种组织制备的胞质组分中NAD+依赖性15-羟基前列腺素脱氢酶的活性。在所研究的不同组织中，该酶的比活性差异很大。前列腺素脱氢酶的比活性在肾上腺、胎盘和输尿管中最高，而在肾脏、肺和睾丸中为中等水平；在包括心脏、肠道和大脑在内的其他组织中则为低水平或未检测到。人类胎儿组织中前列腺素脱氢酶比活性存在广泛差异的这一发现支持了该酶在调节这些组织中前列腺素水平方面具有重要作用的可能性。