多发性硬化症的遗传因素。来自英格兰东北部的证据。
The genetic contribution to multiple sclerosis. Evidence from North-East England.
作者信息
Roberts D F, Bates D
出版信息
J Neurol Sci. 1982 May;54(2):287-93. doi: 10.1016/0022-510x(82)90189-7.
PMID:7097301
Abstract
A study of 206 patients with multiple sclerosis in the north-east of England and their families shows no evidence of monogenic involvement in the disorder. Much more likely is a multifactorial etiology in which the genetic component is polygenic. On this model the heritability is calculated at 52.1% or 40.9% if age variation in incidence is allowed for. The genetic component is present but no more then moderate in extent.
摘要
一项针对英格兰东北部206名多发性硬化症患者及其家族的研究表明，没有证据显示该疾病存在单基因参与。更有可能的是多因素病因，其中遗传成分是多基因的。根据这个模型，如果考虑发病率的年龄差异，遗传率计算为52.1%或40.9%。遗传成分是存在的，但程度不超过中等。
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