Juntunen J, Taskinen E, Luisto M, Iivanainen M, Nurminen M
J Neurol Sci. 1982 Jun;54(3):413-25. doi: 10.1016/0022-510x(82)90204-0.
Cerebrospinal fluid (CSF) cells and proteins were determined for 33 patients exposed to industrial organic solvents. A lymphoid reaction, i.e., a pathologically elevated number or percentage of enlarged lymphoid cells was observed in one-third of the patients, more often in patients with chronic intoxication (40%) than in those currently exposed to organic solvents (32%). An almost significant decrease of small lymphocytes in the CSF was observed among patients who had a past history of chronic solvent intoxication but no recent exposure. No cytological evidence of tissue destruction was found. Signs of slight blood--CSF barrier damage occurred in 5 (23%) of the currently exposed patients, but intrathecal IgG synthesis was not observed. Increased cellular activity in the CSF was also accentuated in principal component analysis. The results suggest slight nonspecific immunoactivation in the central nervous system of subjects exposed to organic solvents.
对33名接触工业有机溶剂的患者进行了脑脊液（CSF）细胞和蛋白质检测。在三分之一的患者中观察到淋巴样反应，即病理性增多或肿大的淋巴样细胞百分比升高，慢性中毒患者（40%）比当前接触有机溶剂的患者（32%）更常出现这种情况。在有慢性溶剂中毒既往史但近期未接触的患者中，观察到脑脊液中小淋巴细胞几乎显著减少。未发现组织破坏的细胞学证据。5名（23%）当前接触患者出现轻微血脑屏障损伤迹象，但未观察到鞘内IgG合成。主成分分析中也突出显示脑脊液中细胞活性增加。结果提示接触有机溶剂的受试者中枢神经系统存在轻微非特异性免疫激活。
