van de Donk H J, Merkus F W
J Pharm Sci. 1982 May;71(5):595-6. doi: 10.1002/jps.2600710530.
Recently the intranasal application of 5% propranolol was proposed in order to prevent the extensive first-pass metabolism of this drug. The ciliary epithelium in the nose affects the removal of dust, allergens, and microorganisms. The decreasing effect of propranolol on the ciliary beat frequency of human adenoid tissue and chicken embryo tracheas was measured with a photoelectric registration device. After nasal application of 5% propranolol, the drop is diluted by the nasal mucus. It was found that even 0.1% propranolol had a deleterious effect on the cilia of chicken and human tissue. Ciliary movement was arrested irreversibly within 20 min.
最近有人提出经鼻应用5%的普萘洛尔，以防止该药物广泛的首过代谢。鼻腔中的纤毛上皮会影响灰尘、过敏原和微生物的清除。使用光电记录装置测量了普萘洛尔对人腺样体组织和鸡胚气管纤毛搏动频率的降低作用。经鼻应用5%的普萘洛尔后，滴剂会被鼻黏液稀释。结果发现，即使是0.1%的普萘洛尔也会对鸡和人体组织的纤毛产生有害影响。纤毛运动在20分钟内不可逆地停止。
