van de Donk H J, Zuidema J, Merkus F W
Rhinology. 1982 Jun;20(2):81-7.
The effects of benzalkonium chloride, chlorbutol,xylometazoline and naphazoline on the ciliary beat frequency of human adenoids and chicken embryo tracheas have been determined and compared. Chlorbutol 0.5% appeared to arrest ciliary motion in both tissues within 5 minutes. Rinsing with Locke Ringer solution (LR) restored the ciliary motion almost completely in both cases. Benzalkonium chloride 0.006% +EDTA 0.1% decreased the ciliary beat frequency 35% for the human tissues and 50% for the chicken tissues after a contact of 20 minutes. In both cases the frequency hardly changed after rinsing with LR. Naphazoline nitrate 0.1% and xylometazoline HCl 0.05% have reversible effects on the ciliary beat frequency of both human adenoids and chicken embryo tracheas. Cilia of human adenoids appeared to be more sensitive for xylometazoline than for naphazoline; whereas cilia of chicken embryo tracheas were more affected by naphazoline than by xylometazoline. The results with human adenoids and chicken embryo tracheas show a correlation (correlation coeff. = 0.82, p less than 0.005). In the initial response the differences in sensitivity to preservatives and drugs were in many cases statistically significant, but the final effects were similar.
已测定并比较了苯扎氯铵、三氯叔丁醇、赛洛唑啉和萘甲唑啉对人腺样体和鸡胚气管纤毛摆动频率的影响。0.5%的三氯叔丁醇似乎在5分钟内使两种组织中的纤毛运动停止。用洛克林格溶液（LR）冲洗后，两种情况下纤毛运动几乎完全恢复。接触20分钟后，0.006%的苯扎氯铵+0.1%的乙二胺四乙酸（EDTA）使人体组织的纤毛摆动频率降低35%，使鸡组织的纤毛摆动频率降低50%。在两种情况下，用LR冲洗后频率几乎没有变化。0.1%的硝酸萘甲唑啉和0.05%的盐酸赛洛唑啉对人腺样体和鸡胚气管的纤毛摆动频率都有可逆作用。人腺样体的纤毛对赛洛唑啉似乎比对萘甲唑啉更敏感；而鸡胚气管的纤毛受萘甲唑啉的影响比对赛洛唑啉的影响更大。人腺样体和鸡胚气管的结果显示出相关性（相关系数=0.82，p<0.005）。在初始反应中，对防腐剂和药物的敏感性差异在许多情况下具有统计学意义，但最终效果相似。
