Westphal R G, Tindle B, Howard P L, Golden E A, Page G A
Am J Clin Pathol. 1982 Aug;78(2):220-2. doi: 10.1093/ajcp/78.2.220.
Fresh frozen plasma (FFP) normally requires about 45 min to thaw in a 37 degrees C water bath when placed inside an additional plastic overbag. That relatively prolonged time may result in non-utilization or delays in delivery of the product, especially, during emergency surgery. One report recommends the use of a microwave oven to overcome those problems. Most blood banks do not have microwave ovens but usually do have water baths at 56 degrees C. Ten units of FFP thawed inside plastic overbags at 37 degrees C required 49.5 +/- 3.9 min and 22 units thawed at 56 degrees C required 28.3 +/- 4 min to thaw. Removal of the plastic overbag reduces the thawing time to 12-13 min at 56 degrees C. The activity Factor V was 85 +/- 15% (65-106%) at 37 degrees C and 80 +/- 21% (47-118%) at 56 degrees C. Factor VIII activity was 86 +/- 21% (59-118%) at 37 degrees C and 90 +/- 37% (46-225%) at 56 degrees C. There were no demonstrable alterations in fibrinogen, PT, APTT, Factor II, VII, IX, and XI between the two thawing temperatures, even after 24 hours of storage at 4 degrees C.
新鲜冰冻血浆（FFP）放在额外的塑料外袋中时，通常需要在37℃水浴中解冻约45分钟。这段相对较长的时间可能导致该产品无法使用或交付延迟，尤其是在急诊手术期间。一份报告建议使用微波炉来解决这些问题。大多数血库没有微波炉，但通常有56℃的水浴。10单位放在塑料外袋中于37℃解冻的FFP解冻需要49.5±3.9分钟，22单位于56℃解冻需要28.3±4分钟。去除塑料外袋可将56℃时的解冻时间缩短至12 - 13分钟。凝血因子V活性在37℃时为85±15%（65 - 106%），在56℃时为80±21%（47 - 118%）。凝血因子VIII活性在37℃时为86±21%（59 - 118%），在56℃时为90±37%（46 - 225%）。在两种解冻温度下，即使在4℃储存24小时后，纤维蛋白原、PT、APTT、凝血因子II、VII、IX和XI也没有明显变化。
