Tobiasz C, Nicholson C
Brain Res. 1982 Jun 10;241(2):329-33. doi: 10.1016/0006-8993(82)91071-x.
Spreading depression (SD) was elicited in the benzoate-conditioned rat cerebellum by microinjection of KC1. Median SD propagation velocity was 9.2 mm . min-1. [Na+]0 decreases, median value 77.5 mM, were measured with ion-selective micropipettes. Superfusion of the cerebellum with 10-5 M tetrodotoxin did not modify the propagation velocity or decrease the [Na+]0 change. This confirms that classical voltage-mediated Na+ conductances are not involved in SD.
通过微量注射氯化钾在苯甲酸盐预处理的大鼠小脑中引发扩散性抑制（SD）。SD的中位传播速度为9.2毫米·分钟⁻¹。用离子选择性微电极测量到细胞外[Na⁺]浓度（[Na⁺]₀）下降，中位值为77.5毫摩尔/升。用10⁻⁵摩尔/升的河豚毒素对小脑进行灌流，并未改变传播速度，也未减少[Na⁺]₀的变化。这证实了经典的电压介导的Na⁺电导不参与扩散性抑制。
