Kalivas P W, Gau B A, Nemeroff C B, Prange A J
Brain Res. 1982 Jul 15;243(2):279-86. doi: 10.1016/0006-8993(82)90251-7.
Neurotensin (NT) is an endogenous peptide which has been hypothesized to function in the central nervous systems as a neurotransmitter. Injection of NT into the cerebral ventricular system of rodents produces antinociception in a variety of analgesia tests. In the hot plate test, direct microinjection of NT into the central nucleus of the amygdala (AC) produced a significant increase in the nociceptive threshold of the rat, while injections into tissue adjacent to the AC were generally ineffective. Antinociception following intra-AC injection of NT occurred at an ED50 dose of 2.4 micrograms NT, and was significantly lower than the ED50 dose observed when NT was given into the lateral ventricles (93.2 micrograms NT). Lesions of the stria terminalis totally abolished the antinociceptive effect of intra-AC administration of NT, indicating that AC efferent or afferent fibers within the stria terminalis are necessary for the observed increase in nociceptive threshold.
神经降压素（NT）是一种内源性肽，据推测它在中枢神经系统中作为神经递质发挥作用。向啮齿动物的脑室系统注射NT在多种镇痛试验中产生抗伤害感受作用。在热板试验中，将NT直接微量注射到杏仁核中央核（AC）可使大鼠的伤害感受阈值显著提高，而注射到AC相邻组织通常无效。AC内注射NT后的抗伤害感受作用在NT剂量为2.4微克时达到半数有效剂量（ED50），且明显低于向侧脑室注射NT时观察到的ED50剂量（93.2微克NT）。终纹床核损伤完全消除了AC内注射NT的抗伤害感受作用，表明终纹床核内的AC传出或传入纤维对于观察到的伤害感受阈值升高是必需的。
