正常成年人空腹尿羟脯氨酸与肌酐比值的测定及其随年龄和性别的变化。
Measurement of the fasting urinary hydroxyproline: creatinine ratio in normal adults and its variation with age and sex.
作者信息
Hodgkinson A, Thompson T
出版信息
J Clin Pathol. 1982 Aug;35(8):807-11. doi: 10.1136/jcp.35.8.807.
Abstract
Conditions for the determination of the fasting urinary hydroxyproline: creatinine ratio (OHPr: Cr ratio) have been examined, using a resin-catalysed hydrolysis and automated colorimetric procedure for the determination of hydroxyproline. Feeding experiments with gelatin showed that hydroxyproline is rapidly absorbed and excreted in the urine and that a 12-hour (overnight) fast is sufficient to ensure correct and reproducible fasting OHPr: Cr ratios. The mean fasting OHPr: Cr ratio decreased slightly with increasing age in both men and premenopausal women but there was no significant difference between the sexes. There was, however, a significant increase in the mean ratio in postmenopausal women. The normal range of fasting OHPr: Cr ratios for men and premenopausal women was found to be 0.003--0.015.
摘要
已对测定空腹尿羟脯氨酸
肌酐比值（OHPr:Cr比值）的条件进行了研究，采用树脂催化水解和自动比色法测定羟脯氨酸。用明胶进行的喂养实验表明，羟脯氨酸能迅速被吸收并经尿液排出，且禁食12小时（过夜）足以确保获得正确且可重复的空腹OHPr:Cr比值。男性和绝经前女性的空腹OHPr:Cr比值平均值均随年龄增长略有下降，但两性之间无显著差异。然而，绝经后女性的平均比值有显著升高。男性和绝经前女性空腹OHPr:Cr比值的正常范围为0.003--0.015。
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