Van Etta L L, Peterson L R, Fasching C E, Gerding D N
J Infect Dis. 1982 Sep;146(3):423-8. doi: 10.1093/infdis/146.3.423.
The penetration of cephapirin into extravascular spaces of various volumes and ratios of surface area to volume (SA/V) was studied in an in vitro kinetic model. The SA/V ratio was found to be an important determinant of the kinetics of these spaces. The greater the surface area in relation to the volume of the extravascular space, the more closely its kinetics mimicked those of the intravascular space-that is, the higher the absolute peak concentration of drug achieved in the extravascular space, the greater the peak-to-trough fluctuation and the more quickly the peak concentration of drug was reached. Extravascular spaces with similar SA/V ratios demonstrated similar kinetics. Data from various models of extravascular fluid in humans and animals were reviewed, and the kinetics of these extravascular spaces were also found to be determined, at least in part, by the SA/V ratios of the spaces.
在一个体外动力学模型中，研究了头孢匹林在不同体积以及不同表面积与体积比（SA/V）的血管外间隙中的渗透情况。发现SA/V比是这些间隙动力学的一个重要决定因素。相对于血管外间隙的体积，其表面积越大，其动力学就越接近血管内间隙的动力学——也就是说，在血管外间隙中达到的药物绝对峰浓度越高，峰谷波动就越大，药物达到峰浓度的速度就越快。具有相似SA/V比的血管外间隙表现出相似的动力学。回顾了来自人类和动物各种血管外液模型的数据，还发现这些血管外间隙的动力学至少部分地由间隙的SA/V比决定。
