环丙沙星在兔模型中向血管外间隙的渗透情况。
Ciprofloxacin penetration into extravascular spaces in a rabbit model.
作者信息
Nichol K L, Peterson L R, Fasching C E, Gerding D N
出版信息
Antimicrob Agents Chemother. 1984 Dec;26(6):935-6. doi: 10.1128/AAC.26.6.935.
Abstract
Ciprofloxacin penetration into extravascular spaces was studied in a rabbit Visking chamber model. The drug was administered (7 mg/kg) intramuscularly every 4 h for eight doses. Peak and trough drug levels by dose 8 were 1.3 and 0.35 micrograms/ml in serum and 0.61 and 0.50 micrograms/ml in extravascular sites. The ratio of extravascular site to serum free drug area under the drug curve by dose 8 was 91.1%. This potent, new antimicrobial agent appears to distribute freely to extravascular spaces in this animal model.
摘要
在兔Visking室模型中研究了环丙沙星向血管外间隙的渗透情况。每4小时肌肉注射一次药物（7毫克/千克），共注射八剂。第8剂时血清中的药物峰浓度和谷浓度分别为1.3和0.35微克/毫升，血管外部位的药物峰浓度和谷浓度分别为0.61和0.50微克/毫升。第8剂时血管外部位与血清中药物曲线下自由药物面积的比值为91.1%。在该动物模型中，这种强效新型抗菌剂似乎可自由分布至血管外间隙。
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