头孢替坦在接受腹部手术患者的吸引皮肤水疱液和组织匀浆中的渗透情况。
Penetration of cefotetan into suction skin blister fluid and tissue homogenates in patients undergoing abdominal surgery.
作者信息
Mazzei T, Tonelli F, Novelli A, Ficari F, Mazzoni C, Anastasi A, Periti P
机构信息
Department of Pharmacology, University of Florence, Italy.
出版信息
Antimicrob Agents Chemother. 1994 Sep;38(9):2221-3. doi: 10.1128/AAC.38.9.2221.
Abstract
The penetration of cefotetan (2-g intravenous bolus) into the suction blister fluid and tissue homogenates of 11 patients was investigated. Mean concentrations in tissue were significantly lower than contemporary suction blister fluid levels. These data show that the determination of beta-lactam concentrations by the tissue homogenate method may seriously underestimate the actual antibiotic levels in extracellular fluid.
摘要
研究了11例患者静脉注射2克头孢替坦后其在抽吸水疱液和组织匀浆中的渗透情况。组织中的平均浓度显著低于同期抽吸水疱液中的水平。这些数据表明，通过组织匀浆法测定β-内酰胺浓度可能会严重低估细胞外液中的实际抗生素水平。
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