Yaginuma T, Izumi R, Yasui H, Arai T, Kawabata M
Nihon Sanka Fujinka Gakkai Zasshi. 1982 Jul;34(7):939-44.
Eight infertile hyperandrogenic and oligomenorrheic women were investigated for lowering serum testosterone levels and inducing regular ovulation by Shakuyaku-Kanzo-To (mixed extracts of Paeonae Radix and Glycyrrhizae Radix). Serum testosterone levels (50-160 ng/dl) were lowered to less than 50 ng/dl in 7 patients by Shakuyaku-Kanzo-To 5-10 g daily administered for 2-8 weeks. Six of 7 patients ovulated regularly and 2 of 6 patients conceived. Serum LH levels, which were shown to be above 30 mIU/ml in 7 patients were lowered to less than 30 mIU/ml in 5 patients by dexamethasone 1 mg daily administered for 6.5 days. All of these patients ovulated regularly by Shakuyaku-Kanzo-To. No side effects were observed. Thus, Shakuyaku-Kanzo-To is indicated for lowering serum testosterone levels and inducing regular ovulation and pregnancy in infertile hyperandrogenic patients, especially in the patients whose serum LH levels were shown to be lowered to less than 30 mIU/ml by dexamethasone.
对8名不育的高雄激素血症和月经过少的女性进行了研究，以探讨芍药甘草汤（芍药根和甘草根的混合提取物）降低血清睾酮水平并诱导规律排卵的效果。通过每日服用5 - 10克芍药甘草汤，持续2 - 8周，7例患者的血清睾酮水平（50 - 160 ng/dl）降至50 ng/dl以下。7例患者中有6例规律排卵，6例中有2例受孕。7例患者中血清促黄体生成素（LH）水平高于30 mIU/ml，通过每日服用1毫克地塞米松，持续6.5天，5例患者的LH水平降至30 mIU/ml以下。所有这些患者通过芍药甘草汤均规律排卵。未观察到副作用。因此，芍药甘草汤适用于降低不育高雄激素血症患者的血清睾酮水平并诱导规律排卵及妊娠，尤其适用于那些通过地塞米松治疗后血清LH水平降至30 mIU/ml以下的患者。
