Perrone-Capano C, D'Onofrio G, Giuditta A
J Neurochem. 1982 Jan;38(1):52-6. doi: 10.1111/j.1471-4159.1982.tb10852.x.
After the intracranial injection of [methyl-3H]thymidine the specific activity of rat cortical DNA increases rapidly, reaching a maximum at about 5 h. More than half of the radioactive DNA disappears from the tissue in the following few hours. During the same period of time the concentration of radioactive DNA in liver remains essentially constant. Minor variations occur in both organs after 41 h. An apparent rapid turnover of DNA is also present in a fraction of purified neuronal perikarya prepared from the cerebral cortex.
在向大鼠颅内注射[甲基 - 3H]胸苷后，大鼠皮质DNA的比活性迅速增加，在约5小时时达到最大值。在接下来的几个小时内，超过一半的放射性DNA从组织中消失。在同一时间段内，肝脏中放射性DNA的浓度基本保持恒定。41小时后，两个器官均出现微小变化。从大脑皮质制备的一部分纯化神经元胞体中也存在明显快速的DNA周转。
