Wertz P W, Downing D T
Science. 1982 Sep 24;217(4566):1261-2. doi: 10.1126/science.7112128.
In the epidermis of terrestrial vertebrates, lipid lamellae between the horny cells are thought to form a barrier to water loss. The lipids are extruded from living cells after assembly in lamellar granules. This assembly might be promoted by recently identified 1-(3'-O-acyl)-beta-D-glucosyl-N-(omega-hydroxyacyl)sphingosines, which have 30- and 32-carbon hydroxy acids as amides and linoleic acid esterified to glucose. Such a role for these molecules could explain the effects of essential fatty acid deficiency, in which the lamellar granules fail to assemble and the barrier to water diffusion is lost.
在陆生脊椎动物的表皮中，角质细胞之间的脂质片层被认为形成了一道防止水分流失的屏障。这些脂质在层状颗粒中组装后从活细胞中挤出。这种组装可能由最近发现的1-(3'-O-酰基)-β-D-葡萄糖基-N-(ω-羟基酰基)鞘氨醇促进，这些鞘氨醇以30碳和32碳的羟基酸作为酰胺，亚油酸酯化到葡萄糖上。这些分子的这种作用可以解释必需脂肪酸缺乏的影响，在必需脂肪酸缺乏时，层状颗粒无法组装，水分扩散的屏障丧失。
