Ott G, Mikuz G
Dtsch Med Wochenschr. 1982 Sep 17;107(37):1396-9. doi: 10.1055/s-2008-1070137.
A 20-year-old labourer, employed in the metal powder industry, developed increasing shortness of breath and serious urge to cough after 2 1/4 years of exposition to cobalt and tungsten carbide powder. On admission 9 months later pulmonary changes were demonstrated radiographically indicating hard-metal-dust lung. Detailed clinical assessment including transpleural biopsy and lingula resection as well as histochemical investigations and follow-up observations permitted access to the pathogenesis and morphology of the disease. By introduction of steroid treatment, before conclusion of diagnostic steps, limitation of the inflammatory primary reaction was possible inasmuch as loss of pulmonary function could be arrested despite massive, histologically verified, tendency for fibrosis.
一名20岁的金属粉末行业工人，在接触钴和碳化钨粉末2年零3个月后，出现呼吸急促加剧和严重的咳嗽冲动。9个月后入院时，影像学检查显示肺部有变化，提示硬金属尘肺。详细的临床评估，包括经胸活检和舌叶切除，以及组织化学研究和随访观察，有助于了解该疾病的发病机制和形态学。在诊断步骤完成之前，通过引入类固醇治疗，尽管组织学证实有大量纤维化倾向，但仍有可能限制炎症初期反应，从而阻止肺功能丧失。
