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Isolation and mass spectrometric identification of gitoxin metabolites excreted in bile.

作者信息

Kadima L N, Lhoest G, Lesne M

出版信息

Eur J Drug Metab Pharmacokinet. 1982;7(2):111-7. doi: 10.1007/BF03188727.

DOI:10.1007/BF03188727
PMID:7117294
Abstract
摘要

相似文献

1
Isolation and mass spectrometric identification of gitoxin metabolites excreted in bile.胆汁中排泄的吉他洛辛代谢物的分离与质谱鉴定。
Eur J Drug Metab Pharmacokinet. 1982;7(2):111-7. doi: 10.1007/BF03188727.
2
Hepatic clearance of gitoxin. Metabolism and biliary excretion by rabbit isolated liver.洋地黄毒苷的肝清除率。兔离体肝脏的代谢及胆汁排泄
Drug Metab Dispos. 1984 Mar-Apr;12(2):235-41.
3
Studies on the pharmacokinetics and the metabolism of gitoxin in the guinea-pig: II. the enteral absorption and the enterohepatic recirculation.豚鼠中地高辛的药代动力学和代谢研究：II. 肠道吸收和肠肝循环。
Arch Int Pharmacodyn Ther. 1982 Jul;258(1):4-14.
4
Studies on the pharmacokinetics and the metabolism of gitoxin in the guinea-pig: I. Disposition kinetics following an i.v. bolus of 3H-gitoxin.
Arch Int Pharmacodyn Ther. 1980 May;245(1):20-41.
5
Hepatic clearance of gitoxin: pharmacokinetic study on rabbit isolated liver. Influence of protein binding and comparison with digoxin.地高辛毒苷的肝清除率：兔离体肝脏的药代动力学研究。蛋白结合的影响及与地高辛的比较。
Eur J Drug Metab Pharmacokinet. 1983;8(1):1-8. doi: 10.1007/BF03189574.
6
Extraction of digoxin and its metabolites from urine and their separation by Sephadex LH-20 column chromatography.从尿液中提取地高辛及其代谢产物，并通过葡聚糖凝胶LH - 20柱色谱法进行分离。
Clin Biochem. 1976 Feb;9(1):46-52. doi: 10.1016/s0009-9120(76)80013-6.
7
Biliary excretion studies with digoxin in man.
Int J Clin Pharmacol Biopharm. 1977 Jul;15(7):332-4.
8
A further study of the pharmacokinetics of gitoxin in rabbit isolated liver: clearance of 3H-gitoxin.
Eur J Drug Metab Pharmacokinet. 1985 Apr-Jun;10(2):113-20. doi: 10.1007/BF03189704.
9
Uptake and pharmacological effect of gitoxin and gitaloxin in rat and guinea-pig perfused hearts. Comparison with digitoxin and digoxin.洋地黄毒苷和吉他洛苷在大鼠和豚鼠离体灌流心脏中的摄取及药理作用。与地高辛和毛花苷丙的比较。
Arzneimittelforschung. 1980;30(4):614-8.
10
Serum and bile digoxin levels in patients subjected to cholecystectomy with or without choledochostomy.接受或未接受胆总管造口术的胆囊切除术患者的血清和胆汁地高辛水平。
Am Surg. 1987 Jun;53(6):333-6.

本文引用的文献

1
Studies on the pharmacokinetics and the metabolism of gitoxin in the guinea-pig: I. Disposition kinetics following an i.v. bolus of 3H-gitoxin.
Arch Int Pharmacodyn Ther. 1980 May;245(1):20-41.
2
4-Hydroxy-5-oxo-4,5-dihydrobenzo(a)pyrene, a new metabolite of benzo(a)pyrene.4-羟基-5-氧代-4,5-二氢苯并(a)芘，苯并(a)芘的一种新代谢产物。
Eur J Drug Metab Pharmacokinet. 1980;5(1):41-3. doi: 10.1007/BF03189442.
3
Uptake and pharmacological effect of gitoxin and gitaloxin in rat and guinea-pig perfused hearts. Comparison with digitoxin and digoxin.洋地黄毒苷和吉他洛苷在大鼠和豚鼠离体灌流心脏中的摄取及药理作用。与地高辛和毛花苷丙的比较。
Arzneimittelforschung. 1980;30(4):614-8.
4
Studies on cardioactive steroids. II. Structure-activity relationships in the isolated guinea-pig heart.
Pharmacology. 1974;11(3):129-38. doi: 10.1159/000136482.
5
Studies on cardioactive steroids. III. Characterization of different cardiac glycosides by their effects on contractility and rhythmicity at different extracellular potassium concentrations.强心甾体的研究。III. 不同强心苷在不同细胞外钾浓度下对收缩性和节律性的影响特征
Acta Biol Med Ger. 1975;34(6):1065-73.
6
Pharmacological reevaluation of gitoxin in man.
Int J Clin Pharmacol Biopharm. 1978 Oct;16(10):456-9.