Sandberg D, Stewart J
J Comp Physiol Psychol. 1982 Aug;96(4):635-48. doi: 10.1037/h0077913.
Daily injections of estradiol benzoate (EB) administered to ovariectomized rats given continuous access to a 10% ethanol solution, to water, and to laboratory chow led to decreases in ethanol consumption. The suppression was transient; ethanol consumption returned to the level of oil-treated control animals after 14 days despite continued hormone administration. This pattern of change in ethanol consumption closely resembled previously reported effects of EB on food intake. It is proposed that a common mechanism was responsible for EB-induced suppression of both food and ethanol intake. Ethamoxytriphetol, MER-25, which antagonizes many estrogen-dependent effects but which mimics the action of EB on food intake, also led to decreases in ethanol consumption that paralleled those reported for food intake. These behavioral effects of EB and MEr-25 were shown not to be due to altered ethanol metabolism or to result from malaise developing out of an interaction between EB and ethanol. It is thus suggested that voluntary consumption of ethanol by the rat is largely due to its caloric content. The relevance of these results for several recent reports of decreased ethanol intake during pregnancy is discussed.
对切除卵巢的大鼠每日注射苯甲酸雌二醇（EB），这些大鼠可自由获取10%的乙醇溶液、水和实验室饲料，结果发现乙醇摄入量减少。这种抑制是短暂的；尽管持续给予激素，但14天后乙醇摄入量恢复到用油处理的对照动物的水平。乙醇摄入量的这种变化模式与先前报道的EB对食物摄入量的影响非常相似。有人提出，EB抑制食物和乙醇摄入是由共同机制引起的。乙胺三苯乙醇（MER - 25）可拮抗许多雌激素依赖性作用，但能模拟EB对食物摄入的作用，它也导致乙醇摄入量减少，其减少情况与报道的食物摄入量减少情况相似。EB和MER - 25的这些行为效应并非由于乙醇代谢改变或EB与乙醇相互作用引起的不适所致。因此表明，大鼠自愿摄入乙醇很大程度上是因其热量含量。文中讨论了这些结果与近期几篇关于孕期乙醇摄入量减少的报道的相关性。
