Park G B, Koss R F, Utter J, Mayes B A, Edelson J
J Pharm Sci. 1982 Aug;71(8):932-4. doi: 10.1002/jps.2600710824.
A reversed-phase liquid chromatographic method for the determination of isoetharine in blood plasma, utilizing amperometric detection, is described. Plasma samples were extracted utilizing an ion-pair reagent, di-(2-ethylhexyl)phosphoric acid, to concentrate the catecholamine. Only minor differences were observed in the relative bioavailability of isoetharine hydrochloride and isoetharine mesylate after oral administration to rats. Observed plasma levels, at 1 hr after oral medication, were highly variable in dose-ranging studies at doses of 800-2500 mg/kg/day for 2 weeks.
本文描述了一种利用安培检测法测定血浆中异丙喘宁的反相液相色谱方法。血浆样品用离子对试剂二（2-乙基己基）磷酸进行萃取，以浓缩儿茶酚胺。给大鼠口服盐酸异丙喘宁和甲磺酸异丙喘宁后，观察到其相对生物利用度仅有微小差异。在剂量范围研究中，口服给药剂量为800 - 2500mg/kg/天，持续2周，服药后1小时观察到的血浆水平变化很大。
