新西兰黑鼠的浆细胞瘤
Plasmacytomas of the NZB mouse.
作者信息
Morse H C, Riblet R, Asofsky R, Weigert M
出版信息
J Immunol. 1978 Nov;121(5):1969-72.
Plasmacytomas were readily induced in NZB mice by three i.p. inoculations with pristane (2, 6, 10, 14-tetramethylpentadecane). In comparison with comparable induction regimens in BALB/c mice a) the latent period for plasmacytoma development was significantly longer in NZB's; b) the frequency of IgA paraproteins produced by NZB tumors was much reduced and that of IgG (IgG1, IgG2a, IgG2b, IgG3Y was significantly increased; and c) the frequency of carbohydrate-binding paraproteins was 10-fold lower. There was a high frequency of primary ascites containing more than one paraprotein, but none of 25 such tumors produced more than one immunoglobulin class on serial transplantation.
通过向NZB小鼠腹腔内接种三次降植烷（2,6,10,14-四甲基十五烷），可轻易诱导出浆细胞瘤。与在BALB/c小鼠中采用的类似诱导方案相比，a）NZB小鼠中浆细胞瘤发生的潜伏期显著更长；b）NZB肿瘤产生的IgA副蛋白频率大幅降低，而IgG（IgG1、IgG2a、IgG2b、IgG3）的频率显著增加；c）碳水化合物结合副蛋白的频率低10倍。含有一种以上副蛋白的原发性腹水频率很高，但在连续移植时，25个此类肿瘤中没有一个产生一种以上免疫球蛋白类别。
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